Treatment for high blood pressure doesn’t seem to be effective…Maybe it’s secondary hypertension!? A doctor provides a thorough explanation

Hypertension progresses without any symptoms and can lead to life-threatening illnesses such as stroke and myocardial infarction. Most of these cases are primary hypertension related to lifestyle habits.Some cases are “secondary hypertension” caused by a disease. Now, we spoke to Dr. Dan (Ube Internal Medicine and Pediatrics Clinic) about the characteristics and treatment of secondary hypertension.

Supervisiondoctor:
Shigeki Dan(Ube Internal Medicine and Pediatrics Clinic)
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Joined the First Department of Internal Medicine, Nihon University School of Medicine (currently Department of Internal Medicine, Division of Blood Collagen Disease), Nihon University School of Medicine. Graduated from the University’s First Graduate School of Internal Medicine and received a doctorate in medicine.
Doctor explains basic knowledge of progress

Editorial department
What is high blood pressure?
Mr. Dan
Blood pressure is the pressure exerted on blood vessels, and is determined by the amount of blood pumped by the heart and the stiffness of the blood vessels.
Editorial department
High blood pressure makes you more susceptible to other diseases.
Mr. Dan
When blood pressure remains high, it causes severe damage to blood vessels. Damaged blood vessels become harder and more likely to cause arteriosclerosis, which in turn causes blood pressure to rise further, creating a vicious cycle. A major problem is that blood flow throughout the body changes rapidly, increasing the risk of serious illness.
Editorial department
How high does it take to be diagnosed as having high blood pressure?
Mr. Dan
According to the diagnostic criteria of the Japanese Society of Hypertension, hypertension is defined as home blood pressure of 135 mmHg or more in the critical period or 85 mmHg or more in the diastolic period, and blood pressure in the office of 140 mmHg or more in the critical period or 90 mmHg or more in the diastolic period.
Editorial department
There are many people in Japan with high blood pressure, so could you please help me?
Mr. Dan
In Japan, there are so many people with high blood pressure that it is sometimes called a national disease. It is estimated that 43 million people have high blood pressure, which is approximately 1 in 3 Japanese people. It is especially common among middle-aged and elderly people, and is strongly influenced by lifestyle habits such as a diet high in salt, lack of exercise, obesity, and stress.
Characteristics and causes of secondary hypertension

Editorial department
Why is secondary hypertension common?
Mr. Dan
There can be various reasons. One of the reasons is that high blood pressure itself does not have any symptoms, many people postpone the problem just because their blood pressure is high, and in the case of secondary hypertension, it is difficult to distinguish it from primary hypertension when there is another disease that is controlling blood pressure. Not only people who have symptoms, but also young people with high blood pressure, people whose blood pressure suddenly rises, and people whose blood pressure does not go down even with medication may have secondary hypertension.
Editorial department
What are the causes?
Mr. Dan
Typical examples include renovascular hypertension, which causes a sudden increase in blood flow to the kidneys, sexual hyperaldosteronism, which causes tumors in the adrenal glands to secrete excessive hormones, and pheochromocytoma, and sleep apnea syndrome. It may also be affected by certain medications, such as steroids. Identifying the cause and treating it Accurate diagnosis is important because blood pressure may improve.
Editorial department
What happens if secondary hypertension is left untreated?
Mr. Dan
This can lead to serious complications such as stroke, myocardial infarction, and kidney failure. Young people in particular tend to be cautious and think that they are still fine, but early detection and treatment can significantly shorten their healthy life expectancy. This is not a secondary restriction, but the same applies to current hypertension.
Editorial department
What kind of tests are used for diagnosis?
Mr. Dan
We investigate the cause using blood and urine tests, abdominal echocardiography, and imaging tests such as CT and MRI. Considering the burden on the patient, we start with relatively simple tests and proceed with specialized tests as necessary.
Treatment of secondary hypertension requires early treatment

Editorial department
How does secondary hypertension treatment proceed?
Mr. Dan
The key is to treat the underlying disease. Treatment methods vary depending on the disease, such as kidney treatment for kidney disease, surgery for adrenal tumors, and CPAP therapy for sleep apnea syndrome. If drug-induced hypertension is suspected, consider and implement discontinuation or reduction of the suspected drug.
Editorial department
Do you also take antihypertensive drugs?
Mr. Dan
yes. Medications that lower blood pressure are used in parallel with treatment of the underlying disease to prevent complications.
Editorial department
Also, is there anything I should know about secondary hypertension?
Mr. Dan
This is a bit technical, but the aforementioned primary hyperaldosteronism has traditionally been said to be “diagnosed by hypokalemia,” but in reality, about half of patients have normal potassium levels.
Editorial department
Lastly, please give a message to our readers.
Mr. Dan
If high blood pressure is left untreated, there is a risk of various diseases. If common treatments are not effective, it is important to consider the possibility of secondary hypertension. Many people think that the sun gets higher in the morning, but it is actually said that it is often highest in the morning.
Editorial department summary
Most cases of high blood pressure are related to lifestyle habits, but some cases are secondary hypertension caused by diseases. Especially in young people and people for whom it is difficult to take medication, if you do not leave the condition untreated, you will need to be examined at a medical institution. If left untreated, there is a risk of serious complications for the brain, heart, and kidneys, so if you have been diagnosed with high blood pressure, please consider taking this as soon as possible.
Clinic information

Ube Internal Medicine Pediatric Clinic
| location | 1-13-14 Ota Nishi Kojidani, Tokyo |
| Medical subject | Allergy, internal medicine, respiratory medicine, pediatrics, cardiovascular medicine |
| Medical hours | Morning: Mon-Fri 9:00-12:30, Sat 9:00-13:00 Afternoon: Monday, Tuesday, Wednesday, and Friday 15:00-18:00 |
| Closed days | Thursday afternoon, Sunday |