Toei Shinyaku Co., Ltd. has confirmed through human clinical trials that ingestion of open-grown Agaricus KA21 focuses on improving symptoms associated with andropause (LOH syndrome), such as decreased sexual desire, erectile dysfunction (ED), depression, and muscle weakness.
■About receipt of patent decision
Toei Shinyaku Co., Ltd. (location: Mitaka City, Tokyo, CEO: Akitomo Motoi) has confirmed through joint research with the Shigakukan University School of Health Sciences that ingestion of the open-grown Agaricus KA21 strain (hereinafter referred to as Agaricus KA21) has the potential to improve multiple symptoms associated with andropause.
Based on the results of this research, we
“Compositions for improving male menopausal symptoms such as decreased sexual desire, erectile dysfunction (ED), depression, and muscle weakness, and pharmaceuticals and foods containing the same for preventing and improving male menopausal symptoms.”
We would like to inform you that we have received a patent grant from the Japan Patent Office.
We are currently proceeding with patent registration procedures and are scheduled to receive a patent certificate in approximately 1 to 1.5 months.
■Summary
Compositions for improving male menopausal symptoms such as decreased sexual desire, erectile dysfunction (ED), depression, and muscle weakness, and pharmaceuticals and foods containing the same for preventing and improving male menopausal symptoms
■Summary of human clinical trial data
We asked 24 men aged 50 to under 70 to take 900mg of open-grown Agaricus KA21 per day for two months, and compared the indicators associated with andropause symptoms when drinking slowly.
As a result, statistically conscious improvements were confirmed for the following evaluation indicators.
The results of this study were presented at the 25th General Meeting of the Japanese Society of Anti-Aging Medicine.
AMS score (comprehensive evaluation index of andropause symptoms)***
EHS score (durability hardness evaluation)*
SHIM score (male sexual health evaluation index)*
Hair loss condition *
*P＜0.05, ***P＜0.001
■About male menopause
Testosterone, a male hormone, plays an important role in maintaining men’s physical and mental functions. It is closely related to sarcopenia, a condition such as loss of muscle mass and muscle weakness, and there are concerns about the causes and preventive effects of a wide range of diseases, including angina pectoris, arteriosclerosis, obesity, metabolic syndrome, and dementia. This is called onset hypogonadism (LOH syndrome).
Aging male hypogonadism syndrome (LOH) causes a variety of symptoms, including general fatigue, decreased sexual desire, lack of motivation, erectile dysfunction (ED), decreased concentration, insomnia, irritability, stiff shoulders, urinary problems, a heavy head, and decreased awakening in the early morning. Decreased telone levels increase the risk of a variety of health problems, including depression, decreased sexual function, decreased cognitive performance, cardiovascular disease, increased visceral fat, worsened insulin resistance, decreased good cholesterol (HDL), and increased total sterol and bad cholesterol (LDL) levels.
(From the Japan Men’s Health Medicine Association website)
■About Agaricus
Agaricus is a type of mushroom that has been used as a health food in complementary and alternative medicine, and it is known that its component characteristics and quality vary greatly depending on the strain, cultivation conditions, and region of production.
■Brazilian outdoor cultivation Agaricus KA21 strain (Agaricus KA21)
Outdoor-grown Agaricus KA21 is an Agaricus grown outdoors under sunlight in Brazil using the King Agaricus 21 (KA21) strain. Compared to greenhouse-grown Agaricus, which is generally grown in a dark place, it has been confirmed that in addition to having larger fruiting bodies, Agaricus contains more of the main ingredients, β-glucan and vitamin D (*1).
Toei Shinyaku Co., Ltd.’s open-air cultivated Agaricus KA21
Differences in the size of Agaricus
Left: General Agaricus (grown in greenhouse) Right: Agaricus grown in open field
Differences in β-glucan content
Difference between vitamins and minerals
In addition, it has been reported that the antioxidant activity of Agaricus KA21 grown outdoors is more than 5 times higher than that of the greenhouse-grown product (*2), suggesting that differences in the cultivation environment may affect component characteristics and functionality.
Differences in antioxidant activity
*(1) Research by Japan Food Research Center
*(2) International Medicinal Mushroom Journal, 2019. 21(3):31-43.
■About Toei Shinyaku Co., Ltd.
Toei Shinyaku Co., Ltd., as a manufacturer of the open-field cultivated Agaricus KA21 strain, has conducted research and development on the KA21 strain for 30 years and published more than 34 international papers.
We have a track record of joint research with Azabu University School of Veterinary Medicine, Keio University SFC Research Institute, National Center for Geriatrics and Gerontology, Shigakukan University Faculty of Health Sciences, Juntendo University School of Medicine, University of Tokyo Food Safety Research Center, Tokyo Pharmaceutical University Faculty of Pharmaceutical Sciences Department of Immunology, and have published a variety of useful data on open-field cultivated Agaricus KA21.
Brand name: Toei Shinyaku Co., Ltd.
Head Office: 1-11-23 Shimorenjaku, Mitaka City, Tokyo 181-0013
Representative: Representative Director Akitomo Motoi
Capital: 10 million yen