Cavaliers vs. 76ers predictions, odds, spreads, times: Wednesday’s 2026 NBA picks based on proven models

In Wednesday’s Eastern Conference matchup on the NBA schedule, the Cleveland Cavaliers will visit the Philadelphia 76ers. The Cavs (22-19) have won and lost their last six games, most recently losing 123-112 to Utah on Monday. The Sixers (22-16) have won six of their last eight games, including a 115-102 road win at Toronto on Monday.

Tipov takes place from the Xfinity Mobile Arena in Philadelphia at 7pm ET. The latest Cavaliers vs. 76ers odds from DraftKings Sportsbook have Philadelphia as a 1.5-point favorite with an over/under of 235.5 points. Before making the 76ers vs. Cavaliers pick. Check out NBA predictions and betting advice from the SportsLine prediction model..

New users can also target the latest content underdog promo code,good Get a $75 bonus entry when you play $5 with promo code CBSSPORTS2 with selected.

The SportsLine projection model simulates every NBA game 10,000 times and has returned well over $10,000 on $100 player bets on top-rated NBA picks over the past eight seasons. The model enters Week 13 of the 2025-26 NBA season with an impressive 34-15 record with top-rated NBA spread picks dating back to last season. Anyone who follows NBA betting advice at a sportsbook or betting app could have made huge profits.

The model is now simulated 76ers vs. Cavaliers With 10,000 views, we’ve published our coveted NBA picks and betting predictions. you can Visit SportsLine now to check out our model picks. Cavaliers vs. 76ers NBA odds and NBA betting lines are below.

76ers vs. Cavaliers spread:

76ers -1.5 at DraftKings Sportsbook

76ers vs. Cavaliers over/under:

235.5 points

76ers vs. Cavaliers money line:

76ers -114, Cavs -105

76ers vs. Cavaliers picks:

See our picks on SportsLine

Streaming 76ers vs. Cavaliers:

Prefectural security (Try it for free)

New users can check the latest information FanDuel Promo Code to If your first $5 bet wins, you get $300 in bonus bets:

How to pick Cavaliers vs. 76ers

After 10,000 simulations of 76ers vs. Cavs, SportsLine’s model looks like this: The total exceeds (237.5 point). If recent records are any indication, Philadelphia fans should be looking forward to a high-scoring game. The last two matchups between these teams have averaged over 250 points with an average total of 257 points. The Cavs and Sixers have each had an over in their last five games and are 9-1 in their last 10 games combined.

The Sixers have also been overrun as of late, with eight of their last 12 games going over the total. With both teams healthy, 10 players are expected to score 14 or more points tonight, with three of them expected to score 20 or more. With the over hitting well over 50% of simulations, the team is projected to score a total of 240 points.

The model also states that one side of the spread will hit almost 70% of the time. Visit SportsLine to see the model’s NBA picks.

So who will win Cavaliers vs. Sixers and which side of the spread will hit almost 70% of the time? Tune into SportsLine now to see which side of the back spread out between the Sixers and the Cavaliers. All from a model that has earned well over $10,000 on top-rated NBA picks.please check it out.

Latest Update

Today BestUpdate

Top of DayUpdate

Today Best Update