A Japanese study has found that amino acids from algae and cyanobacteria, known for their natural UV protection, may improve skin and heart health. Scientists suggest their findings could lead to the development of functional foods and new cosmetics.
Researchers at Meijo University have discovered that mycosporine-like amino acids (MAA) may inhibit angiotensin-converting enzyme (ACE), which plays a role in blood pressure regulation by controlling the contraction and relaxation of blood vessels.
“We found that MAA can inhibit ACE, suggesting possible previously unrecognized blood pressure-related health benefits,” said Professor Shiro Kageyama of the Graduate School of Environmental and Human Sciences.
The researchers say the results are promising and future studies should test whether practical doses can be achieved through food or cosmetics.
main amino acids
research in Bioscience, Biotechnology, Biochemistry identified two MAAs, Porphyra-334 from dried edible seaweed and GlcHMS326 from cyanobacteria, and compared their antioxidant activity.
Structural differences between GlcHMS326 and Porphyra-334 may impact multiple biological activities (Image provided by Kageyama). Porphyra 334 is found in many countries, and GlcHMS326 has been specially modified with additional chemical groups. Isolated from cyanobacteria from hot springs in Thailand.
This amino acid showed strong but slow antioxidant activity, while Porphyra-334 was better at preventing protein damage associated with glycation, which can accelerate skin aging and contribute to chronic disease. Glycation is the binding of sugar molecules to proteins, reducing their flexibility and function.
Researchers found that Porphyra-334 and GlcHMS326 showed promising results in collagenase inhibition, indicating potential anti-aging benefits. The results were more potent for GlcHMS326.
The researchers tested MAA’s response to heat and light and investigated MAA’s biological activity. Because the results were obtained in a controlled clinical test, the researchers call for further testing in living organisms.
Nutrition and cosmetics interest in natural solutions
Compounds in the seaweed and microorganisms helped the species survive intense sunlight, the researchers said. Algae and cyanobacteria naturally produce MAA as part of their defense system against sunlight.
MAA absorbs harmful UV rays and protects cells from damage. This has become the focus of many scientists and cosmetic companies seeking safer, natural alternatives to UV filters.
Meanwhile, the research team explains that for heart health, commonly prescribed hypertension drugs work by blocking ACEs. This is why nutrition and health researchers are so interested in the ACE inhibitory activity of natural compounds.