SAN FRANCISCO, Jan. 20, 2026 (Globe Newswire) — Brain training reached a tipping point in 2025 after years of snowballing scientific validation. New research on the brain teaser app “BrainHQ” is rapidly increasing has helped dispel skepticismIn 2025, a record number of 70 peer-reviewed publications were published in scientific and medical journals. That amount reflects more than momentum. According to , it shows that a new consensus is emerging. empirical scienceManufacturer of Brain Head Office.

Notable publications in 2025 include groundbreaking studies demonstrating the benefits of BrainHQ in cognitive aging and neurodegenerative conditions, elucidating the underlying biochemical mechanisms behind those benefits, and showing how BrainHQ enhances cognitive resilience in the face of brain health stressors.

“Over the past 20 years, thousands of scientists have been involved in designing, testing, and validating exercises and assessments at BrainHQ. We are grateful to the entire global team.” Dr. Henry MahnkeRepresentative director of Posit Science. “Apparently, 2025 was the year we ‘crossed the chasm’. The evidence has become so overwhelming that independent investigators are increasingly coming to the same conclusion: These exercises are working.”

Reviews and meta-analyses

In 2025, 16 meta-analyses and reviews cited many BrainHQ studies in drawing larger conclusions about cognitive training. For example:

cognitive training research

In addition to reviews, dozens of studies using BrainHQ exercises have been published on the effects of BrainHQ on cognition, psychological resilience, physical health, biochemical brain health, and other topics.

• a widely covered neuroimaging research The study showed that BrainHQ training was the first intervention of any kind to upregulate the production of acetylcholine, a “mindful” chemical that is downregulated with aging and is known to decline sharply with dementia. The increase was shown after just 10 weeks of training, which the researchers said corresponds to about 10 years of rejuvenation, and was proposed as the biochemical mechanism for BrainHQ’s effectiveness. These results prompted the NIA to fund follow-up research into predementia to see if it has the potential to change the course of dementia.
• A large-scale multi-domain lifestyle change attempt, US POINTER research Sponsored by the Alzheimer’s Society, BrainHQ was introduced as cognitive training alongside a modified Mediterranean diet and physical exercise and was found to significantly improve overall cognition.
• Research on fatigue and stress respectively patients with multiple sclerosis and in that caregivers of dementia patients,
• a Study among active military personnel, This showed that BrainHQ (alone and in combination with SMART® training) improved multiple measures of cognitive resilience. This is a key priority for the health and readiness of the U.S. military.

evaluation research

BrainHQ Exercise tracks progress across multiple cognitive domains, but a key component of a long-term brain health strategy relies on continuous, scalable monitoring that can be performed anytime, anywhere. BrainHQ has developed, standardized, and validated dozens of specialized cognitive assessments. These self-administered assessments take just 3 minutes to complete and can be combined into customized cognitive batteries for different needs.

In 2025, six studies were published on the BrainHQ assessment, including:

More than 100 additional studies on BrainHQ are currently underway.

BrainHQ exercises and assessments demonstrate benefits in the following ways: Over 300 peer-reviewed studies. like that Benefits include: It improves cognition (attention, speed, memory, decision-making), quality of life (depressive symptoms, self-confidence and control, health-related quality of life), and real-world activities (health outcomes, balance, driving, workplace activities). BrainHQ is used by major health systems, medical centers, clinics, communities, elite athletes, the military, and other organizations focused on peak performance and resiliency. Consumers can try a free BrainHQ exercise every day. https://www.brainhq.com.

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